Gabriel Birkus Selected Research

GS-9191

5/2011	Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191.
7/2009	GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.

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Gabriel Birkus Research Topics

Disease

3	Infections 01/2019 - 01/2016
2	Bites and Stings (Sting) 11/2022 - 09/2019
2	Human Influenza (Influenza) 01/2017 - 01/2017
2	Neoplasms (Cancer) 01/2010 - 05/2008
1	Virus Diseases (Viral Diseases) 01/2018
1	Diarrhea 01/2014
1	Condylomata Acuminata (Genital Wart) 05/2011
1	Papilloma (Papillomatosis) 07/2009
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 05/2008
1	HIV Infections (HIV Infection) 03/2002
1	Hepatoblastoma 03/2002

Drug/Important Bio-Agent (IBA)

5	NucleotidesIBA 01/2018 - 03/2002
3	Antiviral Agents (Antivirals)IBA 11/2022 - 01/2016
3	Proteins (Proteins, Gene)FDA Link 09/2019 - 01/2017
2	InterferonsIBA 11/2022 - 09/2019
2	NucleosidesIBA 01/2018 - 01/2010
2	EndonucleasesIBA 01/2017 - 01/2017
2	GS-9191IBA 05/2011 - 07/2009
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 11/2022
1	Phosphotransferases (Kinase)IBA 11/2022
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/2022
1	Interleukin-6 (Interleukin 6)IBA 11/2022
1	CytokinesIBA 11/2022
1	Interferon-alpha (Interferon Alfa)IBA 11/2022
1	Toll-Like Receptor 7IBA 11/2022
1	Interleukin-1beta (Interleukin 1 beta)IBA 11/2022
1	MagnesiumIBA 09/2019
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2019
1	Isotretinoin (Accutane)FDA LinkGeneric 01/2019
1	triphosphoric acid (triphosphate)IBA 01/2018
1	RNA-Dependent RNA Polymerase (RNA Dependent RNA Polymerase)IBA 01/2017
1	AcidsIBA 01/2017
1	Staphylococcal Protein A (Protein A)IBA 01/2017
1	Recombinant ProteinsIBA 01/2017
1	vesatolimodIBA 01/2016
1	GS-6620IBA 01/2014
1	ProdrugsIBA 05/2011
1	Cytostatic AgentsIBA 01/2010
1	Clofarabine (Clolar)FDA Link 01/2010
1	Antineoplastic Agents (Antineoplastics)IBA 05/2008
1	rabacfosadineIBA 05/2008
1	Mitochondrial DNA (mtDNA)IBA 03/2002
1	Tenofovir (Viread)FDA Link 03/2002

Therapy/Procedure

1	Immunomodulation 11/2022